Title |
International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study
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Published in |
Radiation Oncology, August 2018
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DOI | 10.1186/s13014-018-1107-x |
Pubmed ID | |
Authors |
Georgia K. B. Halkett, Charles Adam Wigley, Samar M Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie McFadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel, Nigel Spry, on behalf of the EORTC Quality of Life Group |
Abstract |
Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy. Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module's scale structure was examined and validated using standard psychometric analysis techniques. Three items were dropped from the module (QLQ-PRT23 → QLQ-PRT20). Factor analysis identified five factors in the module: bowel control; bloating and gas; emotional function/lifestyle; pain; and leakage. Inter-item correlations were within r = 0.3-0.7. Test-Retest reliability was high. All multi-item scales discriminated between patients showing symptoms and those without symptomology. The module discriminated symptoms from the clinician completed scoring and for age, gender and comorbidities. The EORTC QLQ-PRT20 is designed to be used in addition to the EORTC QLQ-C30 to measure quality of life in patients who receive pelvic radiotherapy. The EORTC QLQ-PRT20 is quick to complete, acceptable to patients, has good content validity and high reliability. Australian and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12609000972224 . |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 3 | 60% |
Ireland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 10% |
Student > Master | 5 | 9% |
Student > Postgraduate | 5 | 9% |
Student > Bachelor | 4 | 7% |
Researcher | 4 | 7% |
Other | 10 | 17% |
Unknown | 24 | 41% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 26% |
Nursing and Health Professions | 10 | 17% |
Psychology | 2 | 3% |
Arts and Humanities | 2 | 3% |
Social Sciences | 2 | 3% |
Other | 4 | 7% |
Unknown | 23 | 40% |