Title |
Genes and brain malformations associated with abnormal neuron positioning
|
---|---|
Published in |
Molecular Brain, November 2015
|
DOI | 10.1186/s13041-015-0164-4 |
Pubmed ID | |
Authors |
Jeffrey J. Moffat, Minhan Ka, Eui-Man Jung, Woo-Yang Kim |
Abstract |
Neuronal positioning is a fundamental process during brain development. Abnormalities in this process cause several types of brain malformations and are linked to neurodevelopmental disorders such as autism, intellectual disability, epilepsy, and schizophrenia. Little is known about the pathogenesis of developmental brain malformations associated with abnormal neuron positioning, which has hindered research into potential treatments. However, recent advances in neurogenetics provide clues to the pathogenesis of aberrant neuronal positioning by identifying causative genes. This may help us form a foundation upon which therapeutic tools can be developed. In this review, we first provide a brief overview of neural development and migration, as they relate to defects in neuronal positioning. We then discuss recent progress in identifying genes and brain malformations associated with aberrant neuronal positioning during human brain development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Thailand | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 137 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 17% |
Researcher | 18 | 13% |
Student > Master | 15 | 11% |
Student > Bachelor | 13 | 9% |
Professor | 7 | 5% |
Other | 24 | 17% |
Unknown | 38 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 33 | 24% |
Medicine and Dentistry | 24 | 17% |
Agricultural and Biological Sciences | 17 | 12% |
Biochemistry, Genetics and Molecular Biology | 10 | 7% |
Nursing and Health Professions | 2 | 1% |
Other | 11 | 8% |
Unknown | 41 | 30% |