Title |
Update on mesenchymal stem cell-based therapy in lupus and scleroderma
|
---|---|
Published in |
Arthritis Research & Therapy, November 2015
|
DOI | 10.1186/s13075-015-0819-7 |
Pubmed ID | |
Authors |
Audrey Cras, Dominique Farge, Thierry Carmoi, Jean-Jacques Lataillade, Dan Dan Wang, Lingyun Sun |
Abstract |
Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15 years, autologous hematopoietic stem cell transplantation has been demonstrated to cure some patients with severe AD refractory to all other available therapies. As a consequence, ADs such as lupus and scleroderma have become an emerging indication for cell therapy. Multipotent mesenchymal stem cells (MSCs), isolated from bone marrow and other sites, display specific immunomodulation and anti-inflammatory properties and appear as ideal tools to treat such diseases. The present update aims at summarizing recent knowledge acquired in the field of MSC-based therapies for lupus and scleroderma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 2 | 40% |
Canada | 1 | 20% |
Singapore | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 105 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 18% |
Student > Master | 14 | 13% |
Other | 13 | 12% |
Student > Ph. D. Student | 9 | 8% |
Student > Bachelor | 6 | 6% |
Other | 16 | 15% |
Unknown | 31 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 39 | 36% |
Biochemistry, Genetics and Molecular Biology | 9 | 8% |
Immunology and Microbiology | 8 | 7% |
Agricultural and Biological Sciences | 7 | 6% |
Nursing and Health Professions | 4 | 4% |
Other | 9 | 8% |
Unknown | 32 | 30% |