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Attention Score in Context
| Title |
The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
|
|---|---|
| Published in |
Journal of Neuroinflammation, August 2018
|
| DOI | 10.1186/s12974-018-1284-4 |
| Pubmed ID | |
| Authors |
Amanda J. Stock, Anne Kasus-Jacobi, H. Anne Pereira |
| Abstract |
Neutrophils are the innate immune system's first line of defense. Neutrophils play a critical role in protecting the host against infectious pathogens, resolving sterile injuries, and mediating inflammatory responses. The granules of neutrophils and their constituent proteins are central to these functions. Although neutrophils may exert a protective role upon acute inflammatory conditions or insults, continued activity of neutrophils in chronic inflammatory diseases can contribute to tissue damage. Neutrophil granule proteins are involved in a number of chronic inflammatory conditions and diseases. However, the functions of these proteins in neuroinflammation and chronic neuroinflammatory diseases, including Alzheimer's disease (AD), remain to be elucidated. In this review, we discuss recent findings from our lab and others that suggest possible functions for neutrophils and the neutrophil granule proteins, CAP37, neutrophil elastase, and cathepsin G, in neuroinflammation, with an emphasis on AD. These findings reveal that neutrophil granule proteins may exert both neuroprotective and neurotoxic effects. Further research should determine whether neutrophil granule proteins are valid targets for therapeutic interventions in chronic neuroinflammatory diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 16% |
| Student > Bachelor | 15 | 11% |
| Student > Master | 11 | 8% |
| Researcher | 10 | 7% |
| Student > Doctoral Student | 7 | 5% |
| Other | 20 | 14% |
| Unknown | 53 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 17% |
| Neuroscience | 12 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
| Medicine and Dentistry | 10 | 7% |
| Agricultural and Biological Sciences | 8 | 6% |
| Other | 20 | 14% |
| Unknown | 55 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2023.
All research outputs
#1,631,355
of 23,106,934 outputs
Outputs from Journal of Neuroinflammation
#156
of 2,665 outputs
Outputs of similar age
#36,347
of 334,945 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 63 outputs
Altmetric has tracked 23,106,934 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,665 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.