Title |
VIP Regulates the Development & Proliferation of Treg in vivo in spleen
|
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Published in |
Allergy, Asthma & Clinical Immunology, November 2011
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DOI | 10.1186/1710-1492-7-19 |
Pubmed ID | |
Authors |
Anthony M Szema, Sayyed A Hamidi, Marc G Golightly, Todd P Rueb, John J Chen |
Abstract |
Mounting evidence supports a key role for VIP as an anti-inflammatory agent and promoter of immune tolerance. It suppresses TNF-α and other inflammatory cytokines and chemokines, upregulates anti-inflammatory IL-10, and promotes immune tolerant cells called T regulatory (Treg) cells. VIP KO mice have recently been demonstrated to have spontaneous airway and pulmonary perivascular inflammatory responses, as part of asthma-like and pulmonary hypertension phenotypes, respectively. Both inflammatory responses are correctable with VIP. Focusing on this model, we have now investigated the influence of VIP not only on inflammatory cells but also on Treg cells. |
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