Title |
Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
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Published in |
Clinical Epigenetics, November 2015
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DOI | 10.1186/s13148-015-0155-4 |
Pubmed ID | |
Authors |
Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta, Ivana Antonucci |
Abstract |
The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenetics on male reproduction, evidencing at least four different levels at which sperm epigenetic modifications could affect reproduction: (1) spermatogenesis failure; (2) embryo development; (3) outcome of assisted reproduction technique (ART) protocols, mainly as concerning genomic imprinting; and (4) long-term effects during the offspring lifetime. The environmental agents responsible for epigenetic modifications are also examined, suggesting that the control of paternal lifestyle prior to conception could represent in the next future a novel hot topic in the management of human reproduction. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 20% |
United Kingdom | 3 | 15% |
France | 1 | 5% |
Australia | 1 | 5% |
Hong Kong | 1 | 5% |
Spain | 1 | 5% |
Unknown | 9 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 70% |
Scientists | 5 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 4 | 1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Czechia | 1 | <1% |
Argentina | 1 | <1% |
Japan | 1 | <1% |
Unknown | 288 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 49 | 16% |
Student > Master | 38 | 13% |
Student > Bachelor | 36 | 12% |
Researcher | 35 | 12% |
Student > Doctoral Student | 22 | 7% |
Other | 48 | 16% |
Unknown | 69 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 67 | 23% |
Agricultural and Biological Sciences | 53 | 18% |
Medicine and Dentistry | 41 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
Nursing and Health Professions | 6 | 2% |
Other | 31 | 10% |
Unknown | 92 | 31% |