Title |
Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag
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Published in |
Retrovirology, November 2011
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DOI | 10.1186/1742-4690-8-95 |
Pubmed ID | |
Authors |
Matthew W Woods, Jenna N Kelly, Clayton J Hattlmann, Jessica GK Tong, Li S Xu, Macon D Coleman, Graeme R Quest, James R Smiley, Stephen D Barr |
Abstract |
The identification and characterization of several interferon (IFN)-induced cellular HIV-1 restriction factors, defined as host cellular proteins or factors that restrict or inhibit the HIV-1 life cycle, have provided insight into the IFN response towards HIV-1 infection and identified new therapeutic targets for HIV-1 infection. To further characterize the mechanism underlying restriction of the late stages of HIV-1 replication, we assessed the ability of IFNbeta-induced genes to restrict HIV-1 Gag particle production and have identified a potentially novel host factor called HECT domain and RCC1-like domain-containing protein 5 (HERC5) that blocks a unique late stage of the HIV-1 life cycle. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
United States | 2 | 2% |
Netherlands | 1 | 1% |
Unknown | 76 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 26% |
Researcher | 14 | 17% |
Student > Master | 8 | 10% |
Student > Bachelor | 8 | 10% |
Student > Doctoral Student | 6 | 7% |
Other | 10 | 12% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 30% |
Medicine and Dentistry | 13 | 16% |
Biochemistry, Genetics and Molecular Biology | 13 | 16% |
Immunology and Microbiology | 10 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 5 | 6% |
Unknown | 15 | 19% |