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Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag

Overview of attention for article published in Retrovirology, November 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
1 blog
wikipedia
3 Wikipedia pages

Readers on

mendeley
81 Mendeley
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Title
Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag
Published in
Retrovirology, November 2011
DOI 10.1186/1742-4690-8-95
Pubmed ID
Authors

Matthew W Woods, Jenna N Kelly, Clayton J Hattlmann, Jessica GK Tong, Li S Xu, Macon D Coleman, Graeme R Quest, James R Smiley, Stephen D Barr

Abstract

The identification and characterization of several interferon (IFN)-induced cellular HIV-1 restriction factors, defined as host cellular proteins or factors that restrict or inhibit the HIV-1 life cycle, have provided insight into the IFN response towards HIV-1 infection and identified new therapeutic targets for HIV-1 infection. To further characterize the mechanism underlying restriction of the late stages of HIV-1 replication, we assessed the ability of IFNbeta-induced genes to restrict HIV-1 Gag particle production and have identified a potentially novel host factor called HECT domain and RCC1-like domain-containing protein 5 (HERC5) that blocks a unique late stage of the HIV-1 life cycle.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 2 2%
Netherlands 1 1%
Unknown 76 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 26%
Researcher 14 17%
Student > Master 8 10%
Student > Bachelor 8 10%
Student > Doctoral Student 6 7%
Other 10 12%
Unknown 14 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 30%
Medicine and Dentistry 13 16%
Biochemistry, Genetics and Molecular Biology 13 16%
Immunology and Microbiology 10 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 5 6%
Unknown 15 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2015.
All research outputs
#3,233,495
of 22,659,164 outputs
Outputs from Retrovirology
#155
of 1,102 outputs
Outputs of similar age
#26,174
of 238,843 outputs
Outputs of similar age from Retrovirology
#6
of 24 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,102 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,843 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.