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Leptin: role over central nervous system in epilepsy

Overview of attention for article published in BMC Neuroscience, September 2018
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5 tweeters


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21 Mendeley
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Leptin: role over central nervous system in epilepsy
Published in
BMC Neuroscience, September 2018
DOI 10.1186/s12868-018-0453-9
Pubmed ID

Laura Mora-Muñoz, Alejandro Guerrero-Naranjo, Elisa Angélica Rodríguez-Jimenez, Claudio Alberto Mastronardi, Alberto Velez-van-Meerbeke


Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Researcher 4 19%
Student > Master 3 14%
Student > Ph. D. Student 2 10%
Other 1 5%
Other 2 10%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 3 14%
Veterinary Science and Veterinary Medicine 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Social Sciences 2 10%
Psychology 2 10%
Other 4 19%
Unknown 6 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2019.
All research outputs
of 14,242,646 outputs
Outputs from BMC Neuroscience
of 1,067 outputs
Outputs of similar age
of 271,289 outputs
Outputs of similar age from BMC Neuroscience
of 3 outputs
Altmetric has tracked 14,242,646 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,067 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,289 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them