Title |
Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth
|
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Published in |
BMC Biology, November 2011
|
DOI | 10.1186/1741-7007-9-82 |
Pubmed ID | |
Authors |
Lucas P Carlstrom, Jacob H Hines, Steven J Henle, John R Henley |
Abstract |
Chemotropic factors in the extracellular microenvironment guide nerve growth by acting on the growth cone located at the tip of extending axons. Growth cone extension requires the coordination of cytoskeleton-dependent membrane protrusion and dynamic adhesion to the extracellular matrix, yet how chemotropic factors regulate these events remains an outstanding question. We demonstrated previously that the inhibitory factor myelin-associated glycoprotein (MAG) triggers endocytic removal of the adhesion receptor β1-integrin from the growth cone surface membrane to negatively remodel substrate adhesions during chemorepulsion. Here, we tested how a neurotrophin might affect integrin adhesions. |
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Members of the public | 1 | 100% |
Mendeley readers
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