You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Remodeling of nuclear landscapes during human myelopoietic cell differentiation maintains co-aligned active and inactive nuclear compartments
|
|---|---|
| Published in |
Epigenetics & Chromatin, November 2015
|
| DOI | 10.1186/s13072-015-0038-0 |
| Pubmed ID | |
| Authors |
Barbara Hübner, Mariana Lomiento, Fabiana Mammoli, Doris Illner, Yolanda Markaki, Sergio Ferrari, Marion Cremer, Thomas Cremer |
| Abstract |
Previous studies of higher order chromatin organization in nuclei of mammalian species revealed both structural consistency and species-specific differences between cell lines and during early embryonic development. Here, we extended our studies to nuclear landscapes in the human myelopoietic lineage representing a somatic cell differentiation system. Our longterm goal is a search for structural features of nuclei, which are restricted to certain cell types/species, as compared to features, which are evolutionary highly conserved, arguing for their basic functional roles in nuclear organization. Common human hematopoietic progenitors, myeloid precursor cells, differentiated monocytes and granulocytes analyzed by super-resolution fluorescence microscopy and electron microscopy revealed profound differences with respect to global chromatin arrangements, the nuclear space occupied by the interchromatin compartment and the distribution of nuclear pores. In contrast, we noted a consistent organization in all cell types with regard to two co-aligned networks, an active (ANC) and an inactive (INC) nuclear compartment delineated by functionally relevant hallmarks. The ANC is enriched in active RNA polymerase II, splicing speckles and histone signatures for transcriptionally competent chromatin (H3K4me3), whereas the INC carries marks for repressed chromatin (H3K9me3). Our findings substantiate the conservation of the recently published ANC-INC network model of mammalian nuclear organization during human myelopoiesis irrespective of profound changes of the global nuclear architecture observed during this differentiation process. According to this model, two spatially co-aligned and functionally interacting active and inactive nuclear compartments (ANC and INC) pervade the nuclear space. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 36% |
| United States | 4 | 14% |
| Germany | 2 | 7% |
| Austria | 1 | 4% |
| Portugal | 1 | 4% |
| Poland | 1 | 4% |
| Italy | 1 | 4% |
| Guinea | 1 | 4% |
| France | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 5 | 18% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 50% |
| Scientists | 12 | 43% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Netherlands | 1 | 1% |
| Germany | 1 | 1% |
| Mexico | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 61 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 28% |
| Student > Ph. D. Student | 14 | 21% |
| Student > Master | 10 | 15% |
| Student > Bachelor | 4 | 6% |
| Professor | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 10 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 31% |
| Agricultural and Biological Sciences | 21 | 31% |
| Nursing and Health Professions | 3 | 4% |
| Engineering | 3 | 4% |
| Physics and Astronomy | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2020.
All research outputs
#2,275,506
of 24,226,848 outputs
Outputs from Epigenetics & Chromatin
#67
of 591 outputs
Outputs of similar age
#38,065
of 395,440 outputs
Outputs of similar age from Epigenetics & Chromatin
#5
of 16 outputs
Altmetric has tracked 24,226,848 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 591 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,440 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.