Title |
Value of the prognostic nutritional index and weight loss in predicting metastasis and long-term mortality in nasopharyngeal carcinoma
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Published in |
Journal of Translational Medicine, November 2015
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DOI | 10.1186/s12967-015-0729-0 |
Pubmed ID | |
Authors |
Xiao-Jing Du, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin, Jun Ma |
Abstract |
To evaluate the influence of the progonistic nutritional index (PNI) and weight loss on metastasis and long-term mortality in nasopharyngeal carcinoma (NPC). We retrospectively reviewed 694 newly diagnosed patients with non-disseminated, biopsy-proven NPC. Survival analysis was used to evaluate the predictive value of PNI and weight loss. Multivariate analysis demonstrated that a low pre-therapy PNI (< 55.0) was an independent predictor of poor overall survival (OS) (P = 0.012), distant metastasis-free survival (DMFS) (P = 0.011) and progression-free survival (P = 0.012). High weight loss (HWL, weight loss during treatment ≥10 %) was an independent predictor of poor OS (P = 0.001) and DMFS (P = 0.014). Advanced stage disease, female gender, chemotherapy, high white blood cell count, high serum globulin concentration and pre-therapy body-mass index were predictors of HWL. Pre-therapy PNI and weight loss have significant predictive value for metastasis and mortality in patients with NPC. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Egypt | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 22% |
Student > Postgraduate | 4 | 10% |
Lecturer | 4 | 10% |
Researcher | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 12 | 29% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 46% |
Nursing and Health Professions | 8 | 20% |
Psychology | 2 | 5% |
Social Sciences | 2 | 5% |
Unspecified | 1 | 2% |
Other | 1 | 2% |
Unknown | 8 | 20% |