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Prognostic significance of 18FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis

Overview of attention for article published in Cancer Imaging, November 2015
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3 X users
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1 Facebook page

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66 Dimensions

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57 Mendeley
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Title
Prognostic significance of 18FDG PET/CT in colorectal cancer patients with liver metastases: a meta-analysis
Published in
Cancer Imaging, November 2015
DOI 10.1186/s40644-015-0055-z
Pubmed ID
Authors

Qian Xia, Jianjun Liu, Cheng Wu, Shaoli Song, Linjun Tong, Gang Huang, Yuanbo Feng, Yansheng Jiang, Yewei Liu, Ting Yin, Yicheng Ni

Abstract

The role of 18-fluorodeoxyglucose positron emission tomography CT ((18)FDG PET/CT), as a prognostic factor for survival in colorectal cancer patients with liver metastases, is still controversial. We sought to perform a meta-analysis of the literature to address this issue. A systematic literature search was performed to identify the studies that associated (18)FDG PET/CT to clinical survival outcomes of patients with liver metastases. Methodological qualities of the included studies were also assessed. The summarized hazard ratio (HR) was estimated by using fixed- or random-effect model according to heterogeneity between trails. By analyzing a total of 867 patients from 15 studies, we found that PET/CT for metabolic response to the therapy was capable of predicting event-free survival (EFS) and overall survival (OS) with statistical significance, and the HR was 0.45 (95 % confidence interval [CI], 0.26-0.78) and 0.36 (95 % CI, 0.18-0.71), respectively. Furthermore, pre-treatment (18)FDG PET/CT with high standardized uptake value (SUV) was also significantly associated with poorer OS HR, 1.24; (95 % CI, 1.06-1.45). However, we did not find a statistically significant effect of post-treatment SUV for predicting OS HR, 1.68; (95 % CI, 0.63-4.52). The present meta-analysis confirms that (18)FDG PET/CT is a useful tool to help predict survival outcomes in patients with liver metastases.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 18%
Researcher 8 14%
Student > Master 6 11%
Student > Bachelor 6 11%
Student > Postgraduate 4 7%
Other 8 14%
Unknown 15 26%
Readers by discipline Count As %
Medicine and Dentistry 28 49%
Nursing and Health Professions 4 7%
Agricultural and Biological Sciences 2 4%
Engineering 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 7%
Unknown 16 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#15,168,964
of 25,373,627 outputs
Outputs from Cancer Imaging
#194
of 674 outputs
Outputs of similar age
#198,543
of 392,711 outputs
Outputs of similar age from Cancer Imaging
#2
of 6 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 674 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.