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Candida concentrations determined following concentrated oral rinse culture reflect clinical oral signs

Overview of attention for article published in BMC Oral Health, November 2015
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Title
Candida concentrations determined following concentrated oral rinse culture reflect clinical oral signs
Published in
BMC Oral Health, November 2015
DOI 10.1186/s12903-015-0138-z
Pubmed ID
Authors

Hiroaki Tooyama, Takehisa Matsumoto, Kiyonori Hayashi, Kenji Kurashina, Hiroshi Kurita, Mitsuo Uchida, Eriko Kasuga, Takayuki Honda

Abstract

Oral candidiasis is an infection caused by a yeast-like fungus called Candida. Various methods can be used to isolate Candida from the oral cavity. However, it is difficult to correctly and satisfactorily diagnose oral candidiasis because currently no microbiological or laboratory standards based on samples from the oral cavity are available. The aim of this study is to establish a reliable laboratory test for diagnosing oral candidiasis. Oral swab, rinse and concentrated rinse samples were obtained from 200 consecutive outpatients (103 male patients and 97 female patients; mean age, 47.2 years; age range, 9-89 years). Candida colonies from cultured samples were enumerated to compare the sensitivities and specificities of the above sampling methods, and the associations between Candida detection or concentration and the clinical oral signs were examined. The mean colony numbers were 263 ± 590 CFU/swab for the swab method, 2894 ± 6705 CFU/100 μL for the rinse method, and 9245 ± 19,030 CFU/100 μL for the concentrated rinse method. The median numbers were 23 CFU/swab for the swab method, 56 CFU/100 μL for the rinse method, and 485 CFU/100 μL for the concentrated rinse method. Candida was detected in the oral cavity of 33.5 % and 52.0 % of the outpatients by the swab method and concentrated rinse, respectively. Candida concentrations determined by the concentrated rinse were closely related to the severity of the clinical oral signs. The positive predictive values of residual root, redness of the oral mucosa, denture, glossalgia, dry mouth, and taste disorder were useful predictors of oral candidiasis. Concentrated rinse sampling is suitable for evaluating oral candidiasis, and Candida concentrations examined using this method strongly associated with the oral signs associated with Candida infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 24%
Student > Master 10 19%
Other 4 7%
Lecturer 3 6%
Student > Doctoral Student 2 4%
Other 5 9%
Unknown 17 31%
Readers by discipline Count As %
Medicine and Dentistry 22 41%
Immunology and Microbiology 3 6%
Unspecified 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Agricultural and Biological Sciences 2 4%
Other 6 11%
Unknown 17 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2015.
All research outputs
#20,297,343
of 22,834,308 outputs
Outputs from BMC Oral Health
#1,160
of 1,469 outputs
Outputs of similar age
#324,060
of 386,693 outputs
Outputs of similar age from BMC Oral Health
#22
of 31 outputs
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.