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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
|
|---|---|
| Published in |
Molecular Brain, November 2015
|
| DOI | 10.1186/s13041-015-0166-2 |
| Pubmed ID | |
| Authors |
Anshua Ghosh, Karl Peter Giese |
| Abstract |
CaMKII is a remarkably complex protein kinase, known to have a fundamental role in synaptic plasticity and memory formation. Further, CaMKII has also been suggested to be a tau kinase. CaMKII dysregulation may therefore be a modulator of toxicity in Alzheimer's disease, a dementia characterised by aberrant calcium signalling, synapse and neuronal loss, and impaired memory. Here, we first examine the evidence for CaMKII dysregulation in Alzheimer's patients and draw parallels to findings in disease models which recapitulate key aspects of the disease. We then put forward the hypothesis that these changes critically contribute to neurodegeneration and memory impairment in Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 190 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 22% |
| Student > Bachelor | 30 | 16% |
| Student > Master | 26 | 14% |
| Researcher | 19 | 10% |
| Student > Doctoral Student | 11 | 6% |
| Other | 17 | 9% |
| Unknown | 46 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 57 | 30% |
| Biochemistry, Genetics and Molecular Biology | 31 | 16% |
| Agricultural and Biological Sciences | 26 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Medicine and Dentistry | 9 | 5% |
| Other | 12 | 6% |
| Unknown | 43 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2021.
All research outputs
#2,461,652
of 24,677,985 outputs
Outputs from Molecular Brain
#81
of 1,180 outputs
Outputs of similar age
#40,454
of 397,324 outputs
Outputs of similar age from Molecular Brain
#4
of 41 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,180 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.