Title |
Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12and folic acid on fracture incidence
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Published in |
BMC Geriatrics, December 2011
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DOI | 10.1186/1471-2318-11-80 |
Pubmed ID | |
Authors |
Janneke P van Wijngaarden, Rosalie AM Dhonukshe-Rutten, Natasja M van Schoor, Nathalie van der Velde, Karin MA Swart, Anke W Enneman, Suzanne C van Dijk, Elske M Brouwer-Brolsma, M Carola Zillikens, Joyce BJ van Meurs, Johannes Brug, André G Uitterlinden, Paul Lips, Lisette CPGM de Groot |
Abstract |
Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Current observational evidence suggests that an elevated homocysteine concentration and poor vitamin B12 and folate status are associated with an increased fracture risk. As vitamin B12 and folate intake and status play a large role in homocysteine metabolism, it is hypothesized that supplementation with these B-vitamins will reduce fracture incidence in elderly people with an elevated homocysteine concentration. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 50% |
Canada | 1 | 25% |
United States | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 1% |
Netherlands | 1 | <1% |
Unknown | 219 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 54 | 24% |
Student > Ph. D. Student | 31 | 14% |
Student > Bachelor | 27 | 12% |
Researcher | 19 | 9% |
Other | 8 | 4% |
Other | 39 | 17% |
Unknown | 45 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 55 | 25% |
Nursing and Health Professions | 31 | 14% |
Psychology | 21 | 9% |
Biochemistry, Genetics and Molecular Biology | 13 | 6% |
Sports and Recreations | 13 | 6% |
Other | 41 | 18% |
Unknown | 49 | 22% |