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Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

Overview of attention for article published in Journal of Translational Medicine, November 2015
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2 tweeters

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25 Dimensions

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41 Mendeley
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Title
Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue
Published in
Journal of Translational Medicine, November 2015
DOI 10.1186/s12967-015-0732-5
Pubmed ID
Authors

Eduardo García-Fuentes, Concepción Santiago-Fernández, Carolina Gutiérrez-Repiso, María D. Mayas, Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Juan Alcaide, Luis Ocaña-Wilhelmi, Joan Vendrell, Francisco J. Tinahones, Lourdes Garrido-Sánchez

Abstract

A key role for HIF-1α in the promotion and maintenance of dietary obesity has been proposed. We analyzed the association between hypoxia and de novo lipogenesis in human adipose tissue. We studied HIF-1α mRNA and protein expression in fasting status in visceral adipose tissue (VAT) from non-obese and morbidly obese subjects, and in VAT from wild-type and ob/ob C57BL6J mice in both fasting and feeding status. We also analyzed the effect of hypoxia on the VAT mRNA expression of genes involved in lipogenesis. HIF-1α was increased in VAT from morbidly obese subjects. In fasting status, C57BL6J ob/ob mice had a higher VAT HIF-1α mRNA expression than C57BL6J wild-type mice. In feeding status, VAT HIF-1α mRNA expression significantly increased in C57BL6J wild-type, but not in C57BL6J ob/ob mice. In humans, HIF-1α mRNA expression correlated positively with body mass index and insulin resistance. VAT HIF-1α mRNA expression correlated negatively with ACC1, PDHB and SIRT3 mRNA expression, and positively with PPAR-γ. VAT explants incubated in hypoxia showed reduced SIRT3 and increased PPAR-γ, SREBP-1c, ACLY, ACC1 and FASN mRNA expression. Morbidly obese subjects have a higher level of VAT HIF-1α. Postprandial status is associated with an increase in HIF-1α mRNA expression in C57BL6J wild-type mice. Hypoxia alters the mRNA expression of genes involved in de novo lipogenesis in human VAT.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Chile 1 2%
Canada 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 27%
Student > Master 7 17%
Student > Bachelor 6 15%
Student > Postgraduate 5 12%
Lecturer 1 2%
Other 5 12%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 11 27%
Agricultural and Biological Sciences 10 24%
Biochemistry, Genetics and Molecular Biology 7 17%
Neuroscience 2 5%
Environmental Science 1 2%
Other 1 2%
Unknown 9 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#2,964,518
of 6,644,977 outputs
Outputs from Journal of Translational Medicine
#755
of 1,632 outputs
Outputs of similar age
#126,751
of 277,983 outputs
Outputs of similar age from Journal of Translational Medicine
#37
of 82 outputs
Altmetric has tracked 6,644,977 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 1,632 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.