@DanielDSeaton @jmschreiber91 @svheeringen @dagarfield The mechanism also isn’t necessarily about enhancers causing gene activation directly in one step. It’s more likely to be an induced proximity mechanism as described in these papers
1,759 followers
1,759 followers
@jmschreiber91 @svheeringen @dagarfield How likely is this to be due to not sampling enough cell types? Relationship of TADs & functional enhancer->gene effects are unclear. IMO compartmentalization by inducing localized concentration is closer to
748 followers
RT @DaveyLab: Motif co-regulation and co-operativity https://t.co/H7KaW2SkeH #biosignaling
593 followers
Motif co-regulation and co-operativity https://t.co/H7KaW2SkeH #biosignaling