Title |
Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats
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Published in |
Critical Care, September 2010
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DOI | 10.1186/cc9257 |
Pubmed ID | |
Authors |
Frédérique Ganster, Mélanie Burban, Mathilde de la Bourdonnaye, Lionel Fizanne, Olivier Douay, Laurent Loufrani, Alain Mercat, Paul Calès, Peter Radermacher, Daniel Henrion, Pierre Asfar, Ferhat Meziani |
Abstract |
Hydrogen sulfide (H2S) has been shown to improve survival in rodent models of lethal hemorrhage. Conversely, other authors have reported that inhibition of endogenous H2S production improves hemodynamics and reduces organ injury after hemorrhagic shock. Since all of these data originate from unresuscitated models and/or the use of a pre-treatment design, we therefore tested the hypothesis that the H2S donor, sodium hydrosulfide (NaHS), may improve hemodynamics in resuscitated hemorrhagic shock and attenuate oxidative and nitrosative stresses. |
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