Title |
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity
|
---|---|
Published in |
BMC Neuroscience, December 2015
|
DOI | 10.1186/s12868-015-0227-6 |
Pubmed ID | |
Authors |
Daniela Kuzdas-Wood, Lisa Fellner, Melanie Premstaller, Carlijn Borm, Bastiaan Bloem, Deniz Kirik, Gregor K. Wenning, Nadia Stefanova |
Abstract |
Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease characterized by α-synuclein (α-syn) positive oligodendroglial cytoplasmic inclusions. The latter are associated with a neuronal multisystem neurodegeneration targeting central autonomic, olivopontocerebellar and striatonigral pathways, however the underlying mechanisms of neuronal cell death are poorly understood. Previous experiments have shown that oligodendroglial α-syn pathology increases the susceptibility to mitochondrial stress and proteasomal dysfunction leading to enhanced MSA-like neurodegeneration. Here we analyzed whether oligodendroglial α-syn overexpression in a transgenic mouse model of MSA synergistically interacts with focal neuronal excitotoxic damage generated by a striatal injection of quinolinic acid (QA) to affect the degree of striatal neuronal loss. QA injury led to comparable striatal neuronal loss and optical density of astro- and microgliosis in the striatum of transgenic and control mice. Respectively, no differences were identified in drug-induced rotation behavior or open field behavior between the groups. The failure of oligodendroglial α-syn pathology to exacerbate striatal neuronal loss resulting from QA excitotoxicity contrasts with enhanced striatal neurodegeneration due to oxidative or proteolytic stress, suggesting that enhanced vulnerability to excitotoxicity does not occur in oligodendroglial α-synucleinopathy like MSA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Italy | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 25% |
Student > Bachelor | 3 | 15% |
Researcher | 3 | 15% |
Professor | 2 | 10% |
Other | 1 | 5% |
Other | 3 | 15% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 20% |
Neuroscience | 4 | 20% |
Nursing and Health Professions | 2 | 10% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Computer Science | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |