Title |
Clinical phenotype and allergen sensitization in the first 2 years as predictors of atopic disorders at age 5 years
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Published in |
World Allergy Organization Journal, December 2015
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DOI | 10.1186/s40413-015-0082-z |
Pubmed ID | |
Authors |
Phaik Ling Quah, Evelyn Xiu Ling Loo, Gabriella Nadine Li Yuan Lee, I-Chun Kuo, Irvin Gerez, Genevieve Villablanca Llanora, Yiong Huak Chan, Marion Aw, Lynette Pei-Chi Shek, Bee Wah Lee |
Abstract |
From a birth cohort of at-risk Asian infants, we prospectively investigated the role of early onset allergen sensitization and clinical phenotypes as risk factors for atopic disorders at the age of 5 years. The study recruited 253 families with a history of allergic disease in a first degree relative from an antenatal clinic in Singapore. The children were followed prospectively to assess clinical outcomes and skin prick test was performed at 2 and 5 years of age. Allergen sensitization (food and/or house dust mites) alone at 2 years of age was not associated with increased risk of wheeze and eczema at 5 years. However, the clinical phenotype (eczema and wheeze) with or without the presence of concomitant allergen sensitization at 2 years increased this risk. For eczema, eczema alone at year 2 increased the risk of eczema at year 5 (adjOR = 7.1; 95 % CI: 1.8-27.8) and this was further increased by the presence of allergen sensitization (adjOR = 25.4; 95 % CI: 4.7-138.5) and the concomitant presence of both wheeze and allergen sensitization (adjOR = 64.9; 95 % CI: 4.7-900.0). For wheeze, wheeze alone at 2 years (adjOR = 4.5; 95 % CI: 1.4 -14.8), and wheeze with concomitant allergen sensitization and eczema (adjOR = 13.9; 95 % CI: 1.2-168.5) increased the risk of wheeze at 5 years. The exception was rhinitis, where allergen sensitization alone at 2 years (adjOR = 5.6; 95 % CI: 1.1-29.2) increased the risk of rhinitis at 5 years. Early onset of eczema at 2 years also increased the risk of rhinitis (adjOR = 6.8; 95 % CI: 2.0-23.1). In this Asian birth cohort, the clinical phenotype (eczema and wheeze) with or without concomitant allergen sensitization in the first 2 years of life were strong predictors of atopic disorders at 5 years. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 23% |
Romania | 2 | 15% |
Spain | 1 | 8% |
Argentina | 1 | 8% |
Unknown | 6 | 46% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 54% |
Scientists | 3 | 23% |
Practitioners (doctors, other healthcare professionals) | 2 | 15% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 33% |
Researcher | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Professor | 2 | 8% |
Lecturer | 1 | 4% |
Other | 4 | 17% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 46% |
Nursing and Health Professions | 2 | 8% |
Mathematics | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 33% |