Title |
Image processing for optical mapping
|
---|---|
Published in |
Giga Science, November 2015
|
DOI | 10.1186/s13742-015-0096-z |
Pubmed ID | |
Authors |
Prabu Ravindran, Aditya Gupta |
Abstract |
Optical Mapping is an established single-molecule, whole-genome analysis system, which has been used to gain a comprehensive understanding of genomic structure and to study structural variation of complex genomes. A critical component of Optical Mapping system is the image processing module, which extracts single molecule restriction maps from image datasets of immobilized, restriction digested and fluorescently stained large DNA molecules. In this review, we describe robust and efficient image processing techniques to process these massive datasets and extract accurate restriction maps in the presence of noise, ambiguity and confounding artifacts. We also highlight a few applications of the Optical Mapping system. |
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Sweden | 1 | 33% |
United Kingdom | 1 | 33% |
Hong Kong | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 7% |
Unknown | 26 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 29% |
Researcher | 5 | 18% |
Student > Master | 5 | 18% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Other | 3 | 11% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 18% |
Chemistry | 5 | 18% |
Computer Science | 5 | 18% |
Mathematics | 1 | 4% |
Other | 2 | 7% |
Unknown | 2 | 7% |