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Local molecular analysis of indeterminate thyroid nodules

Overview of attention for article published in Journal of Otolaryngology -- Head & Neck Surgery, December 2015
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Title
Local molecular analysis of indeterminate thyroid nodules
Published in
Journal of Otolaryngology -- Head & Neck Surgery, December 2015
DOI 10.1186/s40463-015-0106-2
Pubmed ID
Authors

Mandeep S. Gill, Smriti Nayan, Linda Kocovski, Jean-Claude Cutz, Stuart D. Archibald, Bernard S. Jackson, James E. M. Young, Michael K. Gupta

Abstract

Thyroid nodules are common but only a minority are malignant. Molecular testing can assist in helping determine whether indeterminate nodules are suspicious for malignancy or benign. The objective of the study was to determine if the analysis of mutations (BRAF, NRAS, KRAS and HRAS) using readily available molecular techniques can help better classify indeterminate thyroid nodules. A retrospective cohort of consecutive patients undergoing diagnostic thyroid surgery were analyzed for the presence or absence of specific mutations known to be associated with thyroid malignancy in FNA samples. Markers chosen were BRAF, NRAS, KRAS and HRAS. All were locally available and currently in use at our centre for other clinical indications. Results from the molecular analysis were then compared to the histopathology from thyroidectomy specimens to determine the sensitivity and specificity of these molecular techniques to classify indeterminate thyroid nodules. Sixty consecutive patients with indeterminate FNAs were recruited. Twenty-three patients had malignant tumors while 37 specimens were benign. Multiple different mutations were identified in the FNA samples. Overall 18 cases had a positive mutation (10 malignant and 8 benign). The sensitivity of BRAF, HRAS, KRAS, and NRAS was 8.7, 8.7, 8.7, and 17.4 respectively while the specificity was100, 83.7, 100 and 94.6. While molecular analysis remains promising, it requires further refinement. Several markers showed promise as good "rule-in" tests.

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Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 67%
Unspecified 1 33%
Readers by discipline Count As %
Unspecified 1 33%
Nursing and Health Professions 1 33%
Medicine and Dentistry 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#7,173,095
of 8,295,152 outputs
Outputs from Journal of Otolaryngology -- Head & Neck Surgery
#169
of 203 outputs
Outputs of similar age
#246,650
of 300,143 outputs
Outputs of similar age from Journal of Otolaryngology -- Head & Neck Surgery
#23
of 26 outputs
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