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Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya

Overview of attention for article published in Parasites & Vectors, December 2015
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3 X users

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75 Mendeley
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Title
Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya
Published in
Parasites & Vectors, December 2015
DOI 10.1186/s13071-015-1223-5
Pubmed ID
Authors

Eric Ochomo, Krishanthi Subramaniam, Brigid Kemei, Emily Rippon, Nabie M. Bayoh, Luna Kamau, Francis Atieli, John M. Vulule, Collins Ouma, John Gimnig, Martin J. Donnelly, Charles Mbogo

Abstract

The voltage gated sodium channel mutation Vgsc-1014S (kdr-east) was first reported in Kenya in 2000 and has since been observed to occur at high frequencies in the local Anopheles gambiae s.s. The mutation Vgsc-1014F has never been reported from An. gambiae Complex complex mosquitoes in Kenya. Molecularly confirmed An. gambiae s.s. (hereafter An. gambiae) and An. arabiensis collected from 4 different parts of western Kenya were genotyped for kdr from 2011 to 2013. Vgsc-1014F was observed to have emerged, apparently, simultaneously in both An. gambiae and An. arabiensis in 2012. A portion of the samples were submitted for sequencing in order to confirm the Vgsc-1014F genotyping results. The resulting sequence data were deposited in GenBank (Accession numbers: KR867642-KR867651, KT758295-KT758303). A single Vgsc-1014F haplotype was observed suggesting, a common origin in both species. This is the first report of Vgsc-1014F in Kenya. Based on our samples, the mutation is present in low frequencies in both An. gambiae and An. arabiensis. It is important that we start monitoring relative frequencies of the two kdr genes so that we can determine their relative importance in an area of high insecticide treated net ownership.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ghana 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 27%
Researcher 12 16%
Student > Ph. D. Student 9 12%
Student > Postgraduate 6 8%
Student > Doctoral Student 3 4%
Other 9 12%
Unknown 16 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 24%
Biochemistry, Genetics and Molecular Biology 16 21%
Nursing and Health Professions 5 7%
Medicine and Dentistry 4 5%
Environmental Science 3 4%
Other 11 15%
Unknown 18 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#14,242,087
of 22,834,308 outputs
Outputs from Parasites & Vectors
#2,825
of 5,467 outputs
Outputs of similar age
#202,781
of 387,568 outputs
Outputs of similar age from Parasites & Vectors
#69
of 149 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,467 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,568 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.