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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Acellular approaches for regenerative medicine: on the verge of clinical trials with extracellular membrane vesicles?
|
|---|---|
| Published in |
Stem Cell Research & Therapy, December 2015
|
| DOI | 10.1186/s13287-015-0232-9 |
| Pubmed ID | |
| Authors |
Almudena Fuster-Matanzo, Florian Gessler, Tommaso Leonardi, Nunzio Iraci, Stefano Pluchino |
| Abstract |
Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathological conditions. In recent years, a number of studies have demonstrated that EVs might hold remarkable potential in regenerative medicine by acting as therapeutically promising nanodrugs. Understanding their final impact on the biology of specific target cells as well as clarification of their overall therapeutic impact remains a matter of intense debate. Here we review the key principles of EVs in physiological and pathological conditions with a specific highlight on the most recently described mechanisms regulating some of the EV-mediated effects. First, we describe the current debates and the upcoming research on EVs as potential novel therapeutics in regenerative medicine, either as unmodified agents or as functionalized small carriers for targeted drug delivery. Moreover, we address a number of safety aspects and regulatory limitations related to the novel nature of EV-mediated therapeutic applications. Despite the emerging possibilities of EV treatments, these issues need to be overcome in order to allow their safe and successful application in future explorative clinical studies. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 138 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 17% |
| Student > Ph. D. Student | 22 | 16% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 13 | 9% |
| Student > Postgraduate | 6 | 4% |
| Other | 23 | 16% |
| Unknown | 32 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 21% |
| Medicine and Dentistry | 27 | 19% |
| Agricultural and Biological Sciences | 15 | 11% |
| Neuroscience | 6 | 4% |
| Immunology and Microbiology | 5 | 4% |
| Other | 18 | 13% |
| Unknown | 40 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#13,217,403
of 22,834,308 outputs
Outputs from Stem Cell Research & Therapy
#914
of 2,420 outputs
Outputs of similar age
#181,848
of 387,655 outputs
Outputs of similar age from Stem Cell Research & Therapy
#33
of 58 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,420 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.