Title |
Concept and application of a computational vaccinology workflow
|
---|---|
Published in |
Immunome Research, November 2010
|
DOI | 10.1186/1745-7580-6-s2-s7 |
Pubmed ID | |
Authors |
Johannes Söllner, Andreas Heinzel, Georg Summer, Raul Fechete, Laszlo Stipkovits, Susan Szathmary, Bernd Mayer |
Abstract |
The last years have seen a renaissance of the vaccine area, driven by clinical needs in infectious diseases but also chronic diseases such as cancer and autoimmune disorders. Equally important are technological improvements involving nano-scale delivery platforms as well as third generation adjuvants. In parallel immunoinformatics routines have reached essential maturity for supporting central aspects in vaccinology going beyond prediction of antigenic determinants. On this basis computational vaccinology has emerged as a discipline aimed at ab-initio rational vaccine design.Here we present a computational workflow for implementing computational vaccinology covering aspects from vaccine target identification to functional characterization and epitope selection supported by a Systems Biology assessment of central aspects in host-pathogen interaction. We exemplify the procedures for Epstein Barr Virus (EBV), a clinically relevant pathogen causing chronic infection and suspected of triggering malignancies and autoimmune disorders. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 2% |
Netherlands | 1 | 2% |
India | 1 | 2% |
Canada | 1 | 2% |
Denmark | 1 | 2% |
United States | 1 | 2% |
Unknown | 58 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 22% |
Student > Ph. D. Student | 12 | 19% |
Student > Master | 10 | 16% |
Student > Doctoral Student | 5 | 8% |
Student > Bachelor | 4 | 6% |
Other | 14 | 22% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 45% |
Computer Science | 5 | 8% |
Medicine and Dentistry | 5 | 8% |
Nursing and Health Professions | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 12 | 19% |
Unknown | 7 | 11% |