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Concept and application of a computational vaccinology workflow

Overview of attention for article published in Immunome Research, November 2010
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Title
Concept and application of a computational vaccinology workflow
Published in
Immunome Research, November 2010
DOI 10.1186/1745-7580-6-s2-s7
Pubmed ID
Authors

Johannes Söllner, Andreas Heinzel, Georg Summer, Raul Fechete, Laszlo Stipkovits, Susan Szathmary, Bernd Mayer

Abstract

The last years have seen a renaissance of the vaccine area, driven by clinical needs in infectious diseases but also chronic diseases such as cancer and autoimmune disorders. Equally important are technological improvements involving nano-scale delivery platforms as well as third generation adjuvants. In parallel immunoinformatics routines have reached essential maturity for supporting central aspects in vaccinology going beyond prediction of antigenic determinants. On this basis computational vaccinology has emerged as a discipline aimed at ab-initio rational vaccine design.Here we present a computational workflow for implementing computational vaccinology covering aspects from vaccine target identification to functional characterization and epitope selection supported by a Systems Biology assessment of central aspects in host-pathogen interaction. We exemplify the procedures for Epstein Barr Virus (EBV), a clinically relevant pathogen causing chronic infection and suspected of triggering malignancies and autoimmune disorders.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Netherlands 1 2%
India 1 2%
Canada 1 2%
Denmark 1 2%
United States 1 2%
Unknown 58 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 22%
Student > Ph. D. Student 12 19%
Student > Master 10 16%
Student > Doctoral Student 5 8%
Student > Bachelor 4 6%
Other 14 22%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 45%
Computer Science 5 8%
Medicine and Dentistry 5 8%
Nursing and Health Professions 3 5%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 12 19%
Unknown 7 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2011.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Immunome Research
#66
of 67 outputs
Outputs of similar age
#104,308
of 110,007 outputs
Outputs of similar age from Immunome Research
#10
of 10 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 67 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.