Title |
Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
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Published in |
Clinical and Molecular Allergy, December 2015
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DOI | 10.1186/s12948-015-0035-7 |
Pubmed ID | |
Authors |
Carina Gabriela Uasuf, Danilo Villalta, Maria Elisabetta Conte, Caterina Di Sano, Maria Barrale, Vincenzo Cantisano, Elisabetta Pace, Mark Gjomarkaj, Sebastiano Gangemi, Ignazio Brusca |
Abstract |
In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy. 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed. All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001). Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy. |
X Demographics
Geographical breakdown
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Romania | 3 | 50% |
Spain | 1 | 17% |
Unknown | 2 | 33% |
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Scientists | 2 | 33% |
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Mendeley readers
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Italy | 1 | 3% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 29% |
Student > Master | 5 | 16% |
Other | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 3 | 10% |
Unknown | 7 | 23% |
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Immunology and Microbiology | 5 | 16% |
Agricultural and Biological Sciences | 3 | 10% |
Computer Science | 1 | 3% |
Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 26% |