Title |
Myeloid-derived suppressor cells in non-neoplastic inflamed organs
|
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Published in |
Inflammation and Regeneration, September 2018
|
DOI | 10.1186/s41232-018-0076-7 |
Pubmed ID | |
Authors |
Sho Sendo, Jun Saegusa, Akio Morinobu |
Abstract |
Myeloid-derived suppressor cells (MDSCs) are a highly heterogeneous population of immature myeloid cells with immunosuppressive function. Although their function in tumor-bearing conditions is well studied, less is known about the role of MDSCs in various organs under non-neoplastic inflammatory conditions. MDSCs are divided into two subpopulations, G-MDSCs and M-MDSCs, and their distribution varies between organs. MDSCs negatively control inflammation in inflamed organs such as the lungs, joints, liver, kidneys, intestines, central nervous system (CNS), and eyes by suppressing T cells and myeloid cells. MDSCs also regulate fibrosis in the lungs, liver, and kidneys and help repair CNS injuries. MDSCs in organs are plastic and can differentiate into osteoclasts and tolerogenic dendritic cells according to the microenvironment under non-neoplastic inflammatory conditions. This article summarizes recent findings about MDSCs under inflammatory conditions, especially with respect to their function and differentiation in specific organs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 19% |
Student > Ph. D. Student | 4 | 15% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Student > Master | 2 | 8% |
Other | 2 | 8% |
Unknown | 9 | 35% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Agricultural and Biological Sciences | 2 | 8% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 35% |