Title |
The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy
|
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Published in |
Stem Cell Research & Therapy, December 2015
|
DOI | 10.1186/s13287-015-0240-9 |
Pubmed ID | |
Authors |
Jun Zhang, Xiaowen Huang, Haijun Wang, Xiaoyan Liu, Tao Zhang, Yunchuan Wang, Dahai Hu |
Abstract |
Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory diseases because of their immunosuppressive and tissue repair properties. Moreover, their immunosuppressive properties and low immunogenicity contribute to a reduced or weakened immune response elicited by the implantation of allogeneic MSCs compared with other cell types. Therefore, implantation of allogeneic MSCs may be a promising cell-based therapy. In this review, we first summarize the unique advantages of allogeneic MSCs for therapeutic applications. Second, we critically analyze the factors influencing their therapeutic effects, including administration routes, detection time-points, disease models, differentiation of MSCs in vivo, and timing and dosage of MSC administration. Finally, current approaches to allogeneic MSC application are discussed. In conclusion, allogeneic MSCs are a promising option because of their low immunogenicity and immunosuppressive and tissue repair capabilities. Further investigations are needed to enhance the consistency and efficacy of MSCs when used as a cell-based therapy in inflammatory diseases as well as for tissue repair. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 25% |
United States | 1 | 13% |
Australia | 1 | 13% |
Russia | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 75% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
France | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 362 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 62 | 17% |
Student > Master | 44 | 12% |
Student > Bachelor | 44 | 12% |
Researcher | 42 | 12% |
Other | 17 | 5% |
Other | 54 | 15% |
Unknown | 102 | 28% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 75 | 21% |
Medicine and Dentistry | 57 | 16% |
Agricultural and Biological Sciences | 48 | 13% |
Veterinary Science and Veterinary Medicine | 17 | 5% |
Engineering | 11 | 3% |
Other | 49 | 13% |
Unknown | 108 | 30% |