Title |
Burkholderia cepacia complex: clinical course in cystic fibrosis patients
|
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Published in |
BMC Pulmonary Medicine, December 2015
|
DOI | 10.1186/s12890-015-0148-2 |
Pubmed ID | |
Authors |
Tania Wrobel Folescu, Claudia Henrique da Costa, Renata Wrobel Folescu Cohen, Orlando Carlos da Conceição Neto, Rodolpho Mattos Albano, Elizabeth Andrade Marques |
Abstract |
Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa. CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group. Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward. Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 15% |
Student > Ph. D. Student | 8 | 15% |
Student > Doctoral Student | 5 | 10% |
Researcher | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 7 | 13% |
Unknown | 15 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Agricultural and Biological Sciences | 5 | 10% |
Immunology and Microbiology | 5 | 10% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 10% |
Unknown | 17 | 33% |