Title |
Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant
|
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Published in |
Military Medical Research, September 2018
|
DOI | 10.1186/s40779-018-0176-3 |
Pubmed ID | |
Authors |
Xiao-rui Zhang, Wen-xia Zhou, Yong-xiang Zhang |
Abstract |
AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 20% |
Researcher | 4 | 16% |
Student > Ph. D. Student | 4 | 16% |
Student > Master | 3 | 12% |
Professor > Associate Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 20% |
Engineering | 4 | 16% |
Chemistry | 4 | 16% |
Agricultural and Biological Sciences | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Other | 2 | 8% |
Unknown | 6 | 24% |