Title |
Suppressive effects of dRYamides on feeding behavior of the blowfly, Phormia regina
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Published in |
Zoological Letters, December 2015
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DOI | 10.1186/s40851-015-0034-z |
Pubmed ID | |
Authors |
Toru Maeda, Yuki Nakamura, Hajime Shiotani, Masaru K. Hojo, Taishi Yoshii, Takanori Ida, Takahiro Sato, Morikatsu Yoshida, Mikiya Miyazato, Masayasu Kojima, Mamiko Ozaki |
Abstract |
Recently, dRYamides-1 and -2 have been identified as ligands of the neuropeptide Y-like receptor CG5811 in Drosophila melanogaster. It has also been reported in brief that injection of dRYamide-1suppresses the early feeding behavior called proboscis extension reflex (PER) in the blowfly Phormia regina. Immunohistochemical analyses by our group using anti-dRYamide-1 antiserum indicated symmetrical localization of 32 immunoreactive cells in the brain of P. regina. In order to analyze the mechanism of feeding regulation, we further investigated the effects of dRYamide-1 and -2 on intake volume, PER exhibition, and activity of the sugar receptor neuron. After injection of dRYamide-1 or -2, flies showed little change in the intake volume of sucrose solution, but a significant depression of PER to sucrose. Injection of dRYamide-1 revealed a significant decrease in the responsiveness of the sugar receptor neuron, although the injection of dRYamide-2 did not. These results suggest that the dRYamide peptides decrease feeding motivation in flies, as evaluated by PER threshold, through a mechanism that partially involves desensitization of the sugar receptor neuron. |
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Geographical breakdown
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Germany | 1 | 5% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 24% |
Other | 2 | 10% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 2 | 10% |
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