Title |
Oral administration of interferon-α2b-transformed Bifidobacterium longum protects BALB/c mice against coxsackievirus B3-induced myocarditis
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Published in |
Virology Journal, December 2011
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DOI | 10.1186/1743-422x-8-525 |
Pubmed ID | |
Authors |
Zhijian Yu, Zhen Huang, Chongwen Shao, Yuanjian Huang, Fan Zhang, Jin Yang, Lili Deng, Zhongming Zeng, Qiwen Deng, Weiseng Zeng |
Abstract |
Multiple reports have claimed that low-dose orally administered interferon (IFN)-α is beneficial in the treatment of many infectious diseases and provides a viable alternative to high-dose intramuscular treatment. However, research is needed on how to express IFN stably in the gut. Bifidobacterium may be a suitable carrier for human gene expression and secretion in the intestinal tract for the treatment of gastrointestinal diseases. We reported previously that Bifidobacterium longum can be used as a novel oral delivery of IFN-α. IFN-transformed B. longum can exert an immunostimulatory role in mice; however the answer to whether this recombinant B. longum can be used to treat virus infection still remains elusive. Here, we investigated the efficacy of IFN-transformed B. longum administered orally on coxsackie virus B3 (CVB3)-induced myocarditis in BALB/c mice. Our data indicated that oral administration of IFN-transformed B. longum for 2 weeks after virus infection reduced significantly the severity of virus-induced myocarditis, markedly down regulated virus titers in the heart, and induced a T helper 1 cell pattern in the spleen and heart compared with controls. Oral administration of the IFN-transformed B. longum, therefore, may play a potential role in the treatment of CVB3-induced myocarditis. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 18% |
Researcher | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Professor > Associate Professor | 2 | 12% |
Student > Master | 2 | 12% |
Other | 3 | 18% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 24% |
Medicine and Dentistry | 3 | 18% |
Immunology and Microbiology | 2 | 12% |
Nursing and Health Professions | 1 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Other | 2 | 12% |
Unknown | 4 | 24% |