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Mendeley readers
Attention Score in Context
| Title |
Intracellular chloride concentration of the mouse vomeronasal neuron
|
|---|---|
| Published in |
BMC Neuroscience, December 2015
|
| DOI | 10.1186/s12868-015-0230-y |
| Pubmed ID | |
| Authors |
SangSeong Kim, Limei Ma, Jay Unruh, Sean McKinney, C. Ron Yu |
| Abstract |
The vomeronasal organ (VNO) is specialized in detecting pheromone and heterospecific cues in the environment. Recent studies demonstrate the involvement of multiple ion channels in VNO signal transduction, including the calcium-activated chloride channels (CACCs). Opening of CACCs appears to result in activation of VNO neuron through outflow of Cl(-) ions. However, the intracellular Cl(-) concentration remains undetermined. We used the chloride ion quenching dye, MQAE, to measure the intracellular Cl(-) concentration of VNO neuron in live VNO slices. The resting Cl(-) concentration in the VNO neurons is measured at 84.73 mM. Urine activation of the VNO neurons causes a drop in Cl(-) concentration, consistent with the notion of an efflux of Cl(-) to depolarize the cells. Similar observation is made for VNO neurons from mice with deletion of the transient receptor potential canonical channel 2 (TRPC2), which have a resting Cl(-) concentrations at 81 mM. The VNO neurons rest at high intracellular Cl(-) concentration, which can lead to depolarization of the cell when chloride channels open. These results also provide additional support of TRPC2-independent pathway of VNO activation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 5% |
| Unknown | 39 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 22% |
| Researcher | 7 | 17% |
| Student > Master | 6 | 15% |
| Student > Bachelor | 4 | 10% |
| Lecturer | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 34% |
| Neuroscience | 8 | 20% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Medicine and Dentistry | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 7 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2015.
All research outputs
#20,298,249
of 22,835,198 outputs
Outputs from BMC Neuroscience
#1,055
of 1,245 outputs
Outputs of similar age
#327,472
of 390,235 outputs
Outputs of similar age from BMC Neuroscience
#34
of 42 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,245 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.