Title |
The secret life of kinases: functions beyond catalysis
|
---|---|
Published in |
Cell Communication and Signaling, October 2011
|
DOI | 10.1186/1478-811x-9-23 |
Pubmed ID | |
Authors |
Jens Rauch, Natalia Volinsky, David Romano, Walter Kolch |
Abstract |
Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Taiwan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Ireland | 1 | <1% |
South Africa | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 239 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 53 | 22% |
Researcher | 50 | 20% |
Student > Master | 33 | 13% |
Student > Bachelor | 21 | 9% |
Student > Doctoral Student | 15 | 6% |
Other | 32 | 13% |
Unknown | 42 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 69 | 28% |
Biochemistry, Genetics and Molecular Biology | 57 | 23% |
Chemistry | 34 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
Medicine and Dentistry | 9 | 4% |
Other | 21 | 9% |
Unknown | 46 | 19% |