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Clonal population expansion in an outbreak of Plasmodium falciparum on the northwest coast of Ecuador

Overview of attention for article published in Malaria Journal, December 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Clonal population expansion in an outbreak of Plasmodium falciparum on the northwest coast of Ecuador
Published in
Malaria Journal, December 2015
DOI 10.1186/s12936-015-1019-2
Pubmed ID
Authors

Fabián E. Sáenz, Lindsay C. Morton, Sheila Akinyi Okoth, Gabriela Valenzuela, Claudia A. Vera-Arias, Eileen Vélez-Álvarez, Naomi W. Lucchi, L. Enrique Castro, Venkatachalam Udhayakumar

Abstract

Determining the source of malaria outbreaks in Ecuador and identifying remaining transmission foci will help in malaria elimination efforts. In this study, the genetic signatures of Plasmodium falciparum isolates, obtained from an outbreak that occurred in northwest Ecuador from 2012 to 2013, were characterized. Molecular investigation of the outbreak was performed using neutral microsatellites, drug resistance markers and pfhrp2 and pfhrp3 genotyping. A majority of parasite isolates (31/32) from this outbreak were of a single clonal type that matched a clonal lineage previously described on the northern coast of Peru and a historical isolate from Ecuador. All but one isolate carried a chloroquine-resistant pfcrt genotype and sulfadoxine- and pyrimethamine-sensitive pfdhps and pfdhfr genotypes. Pfmdr1 mutations were identified in codons 184 and 1042. In addition, most samples (97 %) showed presence of pfhrp2 gene. This study indicates that parasites from a single clonal lineage largely contributed to this outbreak and this lineage was found to be genetically related to a lineage previously reported in the Peruvian coast and historical Ecuadorian parasites.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ecuador 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 23%
Researcher 10 16%
Student > Ph. D. Student 7 11%
Student > Bachelor 6 10%
Student > Postgraduate 3 5%
Other 8 13%
Unknown 14 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 26%
Agricultural and Biological Sciences 13 21%
Medicine and Dentistry 11 18%
Social Sciences 3 5%
Business, Management and Accounting 1 2%
Other 7 11%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2017.
All research outputs
#13,827,402
of 23,569,120 outputs
Outputs from Malaria Journal
#3,478
of 5,653 outputs
Outputs of similar age
#190,078
of 391,614 outputs
Outputs of similar age from Malaria Journal
#77
of 149 outputs
Altmetric has tracked 23,569,120 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,653 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 391,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.