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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditions
|
|---|---|
| Published in |
Veterinary Research, December 2015
|
| DOI | 10.1186/s13567-015-0285-x |
| Pubmed ID | |
| Authors |
Kang Ouyang, Duan-Liang Shyu, Santosh Dhakal, Jagadish Hiremath, Basavaraj Binjawadagi, Yashavanth S. Lakshmanappa, Rui Guo, Russell Ransburgh, Kathryn M. Bondra, Phillip Gauger, Jianqiang Zhang, Terry Specht, Aaron Gilbertie, William Minton, Ying Fang, Gourapura J. Renukaradhya |
| Abstract |
Porcine epidemic diarrhea virus (PEDV) is an economically devastating enteric disease in the swine industry. The virus infects pigs of all ages, but it cause severe clinical disease in neonatal suckling pigs with up to 100% mortality. Currently, available vaccines are not completely effective and feedback methods utilizing PEDV infected material has variable success in preventing reinfection. Comprehensive information on the levels and duration of effector/memory IgA and IgG antibody secreting B cell response in the intestines and lymphoid organs of PEDV-infected sows, and their association with specific antibody levels in clinical samples such as plasma, oral fluid, and feces is important. Therefore, our goal in this study was to quantify PEDV specific IgA and IgG B cell responses in sows at approximately 1 and 6 months post-infection in commercial swine herds, including parity one and higher sows. Our data indicated that evaluation of both PEDV specific IgA and IgG antibody levels in the plasma and oral fluid (but not feces) samples is beneficial in disease diagnosis. PEDV specific B cell response in the intestine and spleen of infected sows decline by 6 months, and this associates with specific antibody levels in the plasma and oral fluid samples; but the virus neutralization titers in plasma remains high beyond 6 months post-infection. In conclusion, in sows infected with PEDV the presence of effector/memory B cell response and strong virus neutralization titers in plasma up to 6 months post-infection, suggests their potential to protect sows from reinfection and provide maternal immunity to neonates, but challenge studies are required to confirm such responses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 71 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 22% |
| Researcher | 13 | 18% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 15 | 21% |
| Agricultural and Biological Sciences | 13 | 18% |
| Medicine and Dentistry | 11 | 15% |
| Nursing and Health Professions | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 15 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Veterinary Research
#1,035
of 1,337 outputs
Outputs of similar age
#292,170
of 396,115 outputs
Outputs of similar age from Veterinary Research
#20
of 29 outputs
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So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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