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Safety of bioabsorbable implants in vitro

Overview of attention for article published in BMC Surgery, December 2015
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Title
Safety of bioabsorbable implants in vitro
Published in
BMC Surgery, December 2015
DOI 10.1186/s12893-015-0111-4
Pubmed ID
Authors

Mehmet Isyar, Ibrahim Yilmaz, Gurdal Nusran, Olcay Guler, Sercan Yalcin, Mahir Mahirogullari

Abstract

The aim of the present study was to investigate the safety of bioabsorbable plates and screws in humans. For this purpose, an implant system based on [poly(lactic-co-glycolic acids)(85:15)] was designed. The system was tested for pH, temperature, and swelling and then its surface morphology was analyzed for surface porosity using environmental electron microscopy. Then, the effects of this bioabsorbable system on the viability and profileration of osteocytes were examined on a molecular level via in vitro experiments. A [poly(lactic-co-glycolic acids)(90:10)] bioabsorbable implant, which is commercially available and used in orthopedic surgery, was used as control group. For the statistical evaluation of the data obtained in the present study, the groups were compared by Tukey HSD test following ANOVA. The significance level was set as p < 0.05. It was observed that the osteocytes cultivated on the PLGA system designed in the present study included more live cells and allowed more proliferation compared to the control. One of the criteria in the selection of implants for orthopedic surgery is that a good implant should not need removal and thus a second surgery. In the present study, a bioabsorbable implant was designed considering this criterion. The present study is the first step to prove the safety of this new design by in vitro toxicity and viability experiments.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 13%
Student > Bachelor 3 13%
Researcher 3 13%
Student > Master 3 13%
Student > Doctoral Student 2 8%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Engineering 5 21%
Medicine and Dentistry 5 21%
Pharmacology, Toxicology and Pharmaceutical Science 4 17%
Veterinary Science and Veterinary Medicine 1 4%
Agricultural and Biological Sciences 1 4%
Other 0 0%
Unknown 8 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#14,702,512
of 22,835,198 outputs
Outputs from BMC Surgery
#309
of 1,321 outputs
Outputs of similar age
#213,609
of 388,813 outputs
Outputs of similar age from BMC Surgery
#2
of 10 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,321 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 388,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.