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Safety of bioabsorbable implants in vitro

Overview of attention for article published in BMC Surgery, December 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
3 tweeters

Citations

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8 Dimensions

Readers on

mendeley
20 Mendeley
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Title
Safety of bioabsorbable implants in vitro
Published in
BMC Surgery, December 2015
DOI 10.1186/s12893-015-0111-4
Pubmed ID
Authors

Mehmet Isyar, Ibrahim Yilmaz, Gurdal Nusran, Olcay Guler, Sercan Yalcin, Mahir Mahirogullari

Abstract

The aim of the present study was to investigate the safety of bioabsorbable plates and screws in humans. For this purpose, an implant system based on [poly(lactic-co-glycolic acids)(85:15)] was designed. The system was tested for pH, temperature, and swelling and then its surface morphology was analyzed for surface porosity using environmental electron microscopy. Then, the effects of this bioabsorbable system on the viability and profileration of osteocytes were examined on a molecular level via in vitro experiments. A [poly(lactic-co-glycolic acids)(90:10)] bioabsorbable implant, which is commercially available and used in orthopedic surgery, was used as control group. For the statistical evaluation of the data obtained in the present study, the groups were compared by Tukey HSD test following ANOVA. The significance level was set as p < 0.05. It was observed that the osteocytes cultivated on the PLGA system designed in the present study included more live cells and allowed more proliferation compared to the control. One of the criteria in the selection of implants for orthopedic surgery is that a good implant should not need removal and thus a second surgery. In the present study, a bioabsorbable implant was designed considering this criterion. The present study is the first step to prove the safety of this new design by in vitro toxicity and viability experiments.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 15%
Student > Bachelor 3 15%
Researcher 3 15%
Student > Master 2 10%
Other 1 5%
Other 3 15%
Unknown 5 25%
Readers by discipline Count As %
Engineering 5 25%
Pharmacology, Toxicology and Pharmaceutical Science 3 15%
Medicine and Dentistry 3 15%
Agricultural and Biological Sciences 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Other 0 0%
Unknown 7 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#3,150,633
of 6,945,952 outputs
Outputs from BMC Surgery
#101
of 319 outputs
Outputs of similar age
#124,847
of 276,583 outputs
Outputs of similar age from BMC Surgery
#4
of 12 outputs
Altmetric has tracked 6,945,952 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 319 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.