Title |
Cold shock proteins: from cellular mechanisms to pathophysiology and disease
|
---|---|
Published in |
Cell Communication and Signaling, September 2018
|
DOI | 10.1186/s12964-018-0274-6 |
Pubmed ID | |
Authors |
Jonathan A. Lindquist, Peter R. Mertens |
Abstract |
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein-1 (YB-1). Biological activities range from the regulation of transcription, splicing and translation, to the orchestration of exosomal RNA content. Indeed, the secretion of YB-1 from cells via exosomes has opened the door to further potent activities. Evidence links a skewed cold shock protein expression pattern with cancer and inflammatory diseases. In this review the evidence for a causative involvement of cold shock proteins in disease development and progression is summarized. Furthermore, the potential application of cold shock proteins for diagnostics and as targets for therapy is elucidated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 29% |
Unknown | 10 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 86% |
Scientists | 1 | 7% |
Unknown | 1 | 7% |
Mendeley readers
Geographical breakdown
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Unknown | 158 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 28 | 18% |
Student > Bachelor | 22 | 14% |
Student > Master | 17 | 11% |
Researcher | 13 | 8% |
Student > Doctoral Student | 11 | 7% |
Other | 14 | 9% |
Unknown | 53 | 34% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 56 | 35% |
Agricultural and Biological Sciences | 22 | 14% |
Medicine and Dentistry | 6 | 4% |
Neuroscience | 4 | 3% |
Immunology and Microbiology | 3 | 2% |
Other | 10 | 6% |
Unknown | 57 | 36% |