Title |
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease
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Published in |
Journal of Neuroinflammation, December 2015
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DOI | 10.1186/s12974-015-0455-9 |
Pubmed ID | |
Authors |
Changyoun Kim, Emmanuel Ojo-Amaize, Brian Spencer, Edward Rockenstein, Michael Mante, Paula Desplats, Wolf Wrasidlo, Anthony Adame, Emeka Nchekwube, Olusola Oyemade, Joseph Okogun, Michael Chan, Howard Cottam, Eliezer Masliah |
Abstract |
Deposition of α-synuclein and neuroinflammation are key pathological features of Parkinson's disease (PD). There is no cure for the disease; however, targeting the pathological features might be available to modulate the disease onset and progression. Hypoestoxide (HE) has been demonstrated as a NF-κB modulator, thereby acting as a potential anti-inflammatory and anti-cancer drug. In order to assess the effect of HE in a mouse model of PD, mThy1-α-syn transgenic mice received intraperitoneal (IP) injections of either vehicle or HE (5 mg/kg) daily for 4 weeks. Treatment of HE decreased microgliosis, astrogliosis, and pro-inflammatory cytokine gene expression in α-syn transgenic mice. HE administration also prevented the loss of dopaminergic neurons and ameliorated motor behavioral deficits in the α-syn transgenic mice, and α-synuclein pathology was significantly reduced by treatment of HE. In addition, increased levels of nuclear phosphorylated NF-κB in the frontal cortex of α-syn transgenic mice were significantly reduced by HE administration. These results support the therapeutic potential of HE for PD and other α-synuclein-related diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 24% |
Student > Master | 6 | 14% |
Researcher | 6 | 14% |
Other | 3 | 7% |
Student > Bachelor | 3 | 7% |
Other | 5 | 12% |
Unknown | 9 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 12 | 29% |
Agricultural and Biological Sciences | 6 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Other | 3 | 7% |
Unknown | 11 | 26% |