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Mendeley readers
Attention Score in Context
| Title |
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands
|
|---|---|
| Published in |
BMC Ecology and Evolution, October 2008
|
| DOI | 10.1186/1471-2148-8-286 |
| Pubmed ID | |
| Authors |
Christian Radauer, Peter Lackner, Heimo Breiteneder |
| Abstract |
The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR-10 family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. In addition, determination of the Bet v 1 structure revealed the existence of a large superfamily of structurally related proteins. In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database. Structural comparisons of representative members of already known protein families structurally related to Bet v 1 with all entries of the Protein Data Bank yielded 47 structures with non-identical sequences. They were classified into eleven families, five of which were newly identified and not included in the Structural Classification of Proteins database release 1.71. The taxonomic distribution of these families extracted from the Pfam protein family database showed that members of the polyketide cyclase family and the activator of Hsp90 ATPase homologue 1 family were distributed among all three superkingdoms, while members of some bacterial families were confined to a small number of species. Comparison of ligand binding activities of Bet v 1-like superfamily members revealed that their functions were related to binding and metabolism of large, hydrophobic compounds such as lipids, hormones, and antibiotics. Phylogenetic relationships within the Bet v 1 family, defined as the group of proteins with significant sequence similarity to Bet v 1, were determined by aligning 264 Bet v 1-related sequences. A distance-based phylogenetic tree yielded a classification into 11 subfamilies, nine exclusively containing plant sequences and two subfamilies of bacterial proteins. Plant sequences included the pathogenesis-related proteins 10, the major latex proteins/ripening-related proteins subfamily, and polyketide cyclase-like sequences. The ubiquitous distribution of Bet v 1-related proteins among all superkingdoms suggests that a Bet v 1-like protein was already present in the last universal common ancestor. During evolution, this protein diversified into numerous families with low sequence similarity but with a common fold that succeeded as a versatile scaffold for binding of bulky ligands. |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | 1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Brazil | 1 | <1% |
| South Africa | 1 | <1% |
| Germany | 1 | <1% |
| India | 1 | <1% |
| Czechia | 1 | <1% |
| Other | 6 | 3% |
| Unknown | 183 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 21% |
| Researcher | 37 | 19% |
| Student > Master | 26 | 13% |
| Student > Bachelor | 25 | 13% |
| Student > Doctoral Student | 12 | 6% |
| Other | 28 | 14% |
| Unknown | 30 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 41% |
| Biochemistry, Genetics and Molecular Biology | 46 | 23% |
| Chemistry | 10 | 5% |
| Immunology and Microbiology | 6 | 3% |
| Medicine and Dentistry | 6 | 3% |
| Other | 9 | 5% |
| Unknown | 40 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2016.
All research outputs
#3,799,086
of 25,374,917 outputs
Outputs from BMC Ecology and Evolution
#998
of 3,714 outputs
Outputs of similar age
#12,333
of 102,797 outputs
Outputs of similar age from BMC Ecology and Evolution
#8
of 35 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,797 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.