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Mendeley readers
| Title |
DNA damage and cellular abnormalities in tuberculosis, lung cancer and chronic obstructive pulmonary disease
|
|---|---|
| Published in |
Multidisciplinary Respiratory Medicine, December 2015
|
| DOI | 10.1186/s40248-015-0034-z |
| Pubmed ID | |
| Authors |
Andréa Lúcia Gonçalves da Silva, Maribel Josimara Bresciani, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Joel Henrique Ellwanger, João Antonio Pêgas Henriques, Andréia Rosane de Moura Valim, Lia Gonçalves Possuelo |
| Abstract |
Tuberculosis (TB), Lung Cancer (LC) and Chronic Obstructive Pulmonary Diseases (COPD) affect millions of individuals worldwide. Monitoring of DNA damage in pathological situations has been investigated because it can add a new dimension to clinical expression and may represent a potential target for therapeutic intervention. The aim of this study was to evaluate DNA damage and the frequency of cellular abnormalities in TB, LC and COPD patients by comparing them to healthy subjects. The detection of DNA damage by a buccal micronucleus cytome assay was investigated in patients with COPD (n = 28), LC (n = 18) and TB (n = 22) and compared to control individuals (n = 17). The COPD group had a higher frequency of apoptotic cells compared to TB and LC group. The TB group showed a higher frequency of DNA damage, defect in cytokinesis, apoptotic and necrotic cells. Patients with LC had low frequency of chromosomal aberrations than TB and COPD patients. COPD patients showed cellular abnormalities that corresponded to cell death by apoptosis and necrosis, while patients with TB presented defects in cytokinesis and dysfunctions in DNA repair that resulted in the formation of micronucleus (MN) besides apoptotic and necrotic cells. Patients with COPD, TB and LC had a low frequency of permanent DNA damage. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| South Africa | 1 | 3% |
| Unknown | 29 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 26% |
| Researcher | 4 | 13% |
| Professor > Associate Professor | 3 | 10% |
| Student > Doctoral Student | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Other | 5 | 16% |
| Unknown | 5 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Agricultural and Biological Sciences | 3 | 10% |
| Unspecified | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 8 | 26% |