Title |
Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways
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Published in |
Virology Journal, December 2011
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DOI | 10.1186/1743-422x-8-530 |
Pubmed ID | |
Authors |
Bin Gu, Guo-Feng Zhang, Ling-Yun Li, Feng Zhou, Dong-Ju Feng, Chuan-Lin Ding, Jing Chi, Chun Zhang, Dan-Dan Guo, Jing-Feng Wang, Hong Zhou, Kun Yao, Wei-Xing Hu |
Abstract |
Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous system (CNS) diseases. HHV-6 is involved in the pathogenesis of encephalitis, multiple sclerosis (MS) and fatigue syndrome. However, the mechanisms responsible for the apoptosis of infected CNS cells induced by HHV-6 are poorly understood. In this study, we investigated the cell death processes of primary human fetal astrocytes (PHFAs) during productive HHV-6A infection and the underlying mechanisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 23% |
Researcher | 5 | 19% |
Professor > Associate Professor | 4 | 15% |
Student > Master | 4 | 15% |
Student > Bachelor | 1 | 4% |
Other | 4 | 15% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 5 | 19% |
Agricultural and Biological Sciences | 3 | 12% |
Immunology and Microbiology | 3 | 12% |
Chemistry | 2 | 8% |
Other | 5 | 19% |
Unknown | 3 | 12% |