Title |
A case study on the potential angiogenic effect of human chorionic gonadotropin hormone in rapid progression and spontaneous regression of metastatic renal cell carcinoma during pregnancy and after surgical abortion
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Published in |
BMC Cancer, December 2015
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DOI | 10.1186/s12885-015-2031-1 |
Pubmed ID | |
Authors |
László Mangel, Krisztina Bíró, István Battyáni, Péter Göcze, Tamás Tornóczky, Endre Kálmán |
Abstract |
Treatment possibilities of metastatic renal cell carcinoma (mRCC) have recently changed dramatically prolonging the overall survival of the patients. This kind of development brings new challenges for the care of mRCC. A 22 year-old female patient with translocation type mRCC, who previously had been treated for nearly 5 years, became pregnant during the treatment break period. Follow-up examinations revealed a dramatic clinical and radiological progression of mRCC in a few weeks therefore the pregnancy was terminated. A few days after surgical abortion, CT examination showed a significant spontaneous regression of the pulmonary metastases, and the volume of the largest manifestation decreased from ca. 30 to 3.5 cm(3) in a week. To understand the possible mechanism of this spectacular regression, estrogen, progesterone and luteinizing hormone receptors (ER, PGR and LHR, respectively) immuno-histochemistry assays were performed on the original surgery samples. Immuno-histochemistry showed negative ER, PGR and positive LHR status suggesting the possible angiogenic effect of human chorionic gonadotropin hormone (hCG) in the background. We hypothesize that pregnancy may play a causal role in the progression of mRCC via the excess amount of hCG, however, more data are necessary to validate the present notions and the predictive role of LHR overexpression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 25% |
Student > Master | 3 | 15% |
Student > Doctoral Student | 2 | 10% |
Researcher | 2 | 10% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 40% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Nursing and Health Professions | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Unknown | 7 | 35% |