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Evolutionary loss of peroxisomes – not limited to parasites

Overview of attention for article published in Biology Direct, December 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)

Mentioned by

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4 tweeters

Citations

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29 Dimensions

Readers on

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34 Mendeley
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Title
Evolutionary loss of peroxisomes – not limited to parasites
Published in
Biology Direct, December 2015
DOI 10.1186/s13062-015-0101-6
Pubmed ID
Authors

Vojtěch Žárský, Jan Tachezy

Abstract

Peroxisomes are ubiquitous eukaryotic organelles that compartmentalize a variety of metabolic pathways that are primarily related to the oxidative metabolism of lipids and the detoxification of reactive oxygen species. The importance of peroxisomes is underscored by serious human diseases, which are caused by disorders in peroxisomal functions. Some eukaryotic lineages, however, lost peroxisomes. These organisms are mainly anaerobic protists and some parasitic lineages including Plasmodium and parasitic platyhelminths. Here we performed a systematic in-silico analysis of peroxisomal markers among metazoans to assess presence of peroxisomes and peroxisomal enzymes. Our analyses reveal an obvious loss of peroxisomes in all tested flukes, tapeworms, and parasitic roundworms of the order Trichocephalida. Intriguingly, peroxisomal markers are absent from the genome of the free-living tunicate Oikopleura dioica, which inhabits oxygen-containing niches of sea waters. We further map the presence and predicted subcellular localization of putative peroxisomal enzymes, showing that in organisms without the peroxisomal markers the set of these enzymes is highly reduced and none of them contains a predicted peroxisomal targeting signal. We have shown that several lineages of metazoans independently lost peroxisomes and that the loss of peroxisomes was not exclusively associated with adaptation to anaerobic habitats and a parasitic lifestyle. Although the reason for the loss of peroxisomes from O. dioica is unclear, organisms lacking peroxisomes, including the free-living O. dioica, share certain typical r-selected traits: high fecundity, limited ontogenesis and relatively low complexity of the gene content. We hypothesize that peroxisomes are generally the first compartment to be lost during evolutionary reductions of the eukaryotic cell. This article was reviewed by Michael Gray and Nick Lane.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 35%
Student > Ph. D. Student 8 24%
Student > Bachelor 4 12%
Professor > Associate Professor 3 9%
Student > Doctoral Student 1 3%
Other 2 6%
Unknown 4 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 47%
Agricultural and Biological Sciences 13 38%
Computer Science 1 3%
Unknown 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2020.
All research outputs
#11,406,243
of 19,097,846 outputs
Outputs from Biology Direct
#314
of 558 outputs
Outputs of similar age
#181,358
of 386,098 outputs
Outputs of similar age from Biology Direct
#38
of 52 outputs
Altmetric has tracked 19,097,846 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 558 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.