Title |
SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
|
---|---|
Published in |
BMC Cancer, December 2011
|
DOI | 10.1186/1471-2407-11-518 |
Pubmed ID | |
Authors |
Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner, Andreas Jung |
Abstract |
The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. |
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