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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, December 2015
|
| DOI | 10.1186/s13195-015-0164-8 |
| Pubmed ID | |
| Authors |
Sanjida Akter, Md. Rajib Hassan, Mohammad Shahriar, Nahia Akter, Md. Golam Abbas, Mohiuddin Ahmed Bhuiyan |
| Abstract |
Studies have shown that proton pump inhibitors (PPIs) increase the brain burden of amyloid-beta (Aβ) and also create vitamin B12 deficiency. However, these two phenomena have deleterious effect on cognition and Alzheimer's disease (AD). Since the use of PPIs has increased tremendously for the last few years, it is of great public health importance to investigate the cognitive impact of PPIs. Hence, the purpose of this study was to investigate the degree of neuropsychological association of each PPI with different cognitive functions. Sixty volunteers of either gender were recruited and divided randomly into six groups: five test groups for five classes of PPIs and one control group. All the groups participated in the five computerized neuropsychological tests (nine subtests) of the Cambridge Neuropsychological Test Automated Battery twice: at the beginning of the study and 7 days thereafter. We found statistically and clinically significant impairment in visual memory, attention, executive function, and working and planning function. One-way analysis of variance findings showed that all PPIs had a similar negative impact on cognition. However, paired-samples t tests indicated that omeprazole showed significant (p < 0.05) results in seven subtests; lansoprazole and pantoprazole showed significant results in five subtests; and rabeprazole showed significant results in four subtests. Among five classes of PPIs, esomeprazole showed comparatively less impact on cognitive function with significant results in three subtests. The present study reveals for the first time that different PPIs have varying degrees of influence on different cognitive domains and have associations with AD. These findings should be considered when balancing the risks and benefits of prescribing these medications. A study done for a longer period of time with a larger sample size might yield better results. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 12% |
| United Kingdom | 2 | 8% |
| Japan | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 18 | 72% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 88% |
| Practitioners (doctors, other healthcare professionals) | 3 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | <1% |
| India | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 129 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 18% |
| Student > Bachelor | 15 | 11% |
| Researcher | 13 | 10% |
| Student > Doctoral Student | 12 | 9% |
| Other | 10 | 8% |
| Other | 21 | 16% |
| Unknown | 37 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 9% |
| Nursing and Health Professions | 11 | 8% |
| Neuroscience | 7 | 5% |
| Psychology | 7 | 5% |
| Other | 26 | 20% |
| Unknown | 37 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#631,638
of 25,728,350 outputs
Outputs from Alzheimer's Research & Therapy
#83
of 1,499 outputs
Outputs of similar age
#10,672
of 399,667 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#4
of 19 outputs
Altmetric has tracked 25,728,350 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,499 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,667 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.