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Correlation between LTR point mutations and proviral load levels among Human T cell Lymphotropic Virus type 1 (HTLV-1) asymptomatic carriers

Overview of attention for article published in Virology Journal, December 2011
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Title
Correlation between LTR point mutations and proviral load levels among Human T cell Lymphotropic Virus type 1 (HTLV-1) asymptomatic carriers
Published in
Virology Journal, December 2011
DOI 10.1186/1743-422x-8-535
Pubmed ID
Authors

Walter K Neto, Antonio C Da-Costa, AnaCarolina S de Oliveira, Vanessa P Martinez, Youko Nukui, Ester C Sabino, Sabri S Sanabani

Abstract

In vitro studies have demonstrated that deletions and point mutations introduced into each 21 bp imperfect repeat of Tax-responsive element (TRE) of the genuine human T-cell leukemia virus type I (HTLV-1) viral promoter abolishes Tax induction. Given these data, we hypothesized that similar mutations may affect the proliferation of HTLV-1-infected cells and alter the proviral load (PvL). To test this hypothesis, we conducted a cross-sectional genetic analysis to compare the near-complete LTR nucleotide sequences that cover the TRE1 region in a sample of HTLV-1 asymptomatic carriers with different PvL burden.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 3%
Brazil 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 24%
Student > Doctoral Student 3 10%
Researcher 3 10%
Student > Ph. D. Student 3 10%
Student > Bachelor 2 7%
Other 6 21%
Unknown 5 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 38%
Medicine and Dentistry 4 14%
Biochemistry, Genetics and Molecular Biology 2 7%
Nursing and Health Professions 2 7%
Immunology and Microbiology 2 7%
Other 2 7%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2011.
All research outputs
#17,652,807
of 22,659,164 outputs
Outputs from Virology Journal
#2,218
of 3,024 outputs
Outputs of similar age
#191,954
of 242,398 outputs
Outputs of similar age from Virology Journal
#66
of 104 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,024 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,398 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.