Title |
Correlation between LTR point mutations and proviral load levels among Human T cell Lymphotropic Virus type 1 (HTLV-1) asymptomatic carriers
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Published in |
Virology Journal, December 2011
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DOI | 10.1186/1743-422x-8-535 |
Pubmed ID | |
Authors |
Walter K Neto, Antonio C Da-Costa, AnaCarolina S de Oliveira, Vanessa P Martinez, Youko Nukui, Ester C Sabino, Sabri S Sanabani |
Abstract |
In vitro studies have demonstrated that deletions and point mutations introduced into each 21 bp imperfect repeat of Tax-responsive element (TRE) of the genuine human T-cell leukemia virus type I (HTLV-1) viral promoter abolishes Tax induction. Given these data, we hypothesized that similar mutations may affect the proliferation of HTLV-1-infected cells and alter the proviral load (PvL). To test this hypothesis, we conducted a cross-sectional genetic analysis to compare the near-complete LTR nucleotide sequences that cover the TRE1 region in a sample of HTLV-1 asymptomatic carriers with different PvL burden. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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South Africa | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 27 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 24% |
Student > Doctoral Student | 3 | 10% |
Researcher | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Bachelor | 2 | 7% |
Other | 6 | 21% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 38% |
Medicine and Dentistry | 4 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 2 | 7% |
Unknown | 6 | 21% |