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The potential clinical value of contrast-enhanced echocardiography beyond current recommendations

Overview of attention for article published in Cardiovascular Ultrasound, January 2016
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Title
The potential clinical value of contrast-enhanced echocardiography beyond current recommendations
Published in
Cardiovascular Ultrasound, January 2016
DOI 10.1186/s12947-015-0045-0
Pubmed ID
Authors

Malin K. Larsson, Cristina Da Silva, Elif Gunyeli, Ali Akebat Bin Ilami, Karolina Szummer, Reidar Winter, Anna Bjällmark

Abstract

Contrast agents are used in resting echocardiography to opacify the left ventricular (LV) cavity and to improve LV endocardial border delineation in patients with suboptimal image quality. If a wider use of contrast-enhanced echocardiography would be adopted instead of the current selective approach, diagnoses such as myocardial ischemia and LV structural abnormalities could potentially be detected earlier. The aim was therefore to retrospectively investigate if contrast-enhanced echocardiography beyond the current recommendations for contrast agent usage affects assessment of wall motion abnormalities, ejection fraction (EF) and detection of LV structural abnormalities. A secondary aim was to evaluate the user dependency during image analysis. Experienced readers (n = 4) evaluated wall motion score index (WMSI) and measured EF on greyscale and contrast-enhanced images from 192 patients without indications for contrast-enhanced echocardiography. Additionally, screening for LV structural abnormalities was performed. Repeated measurements were performed in 20 patients by the experienced as well as by inexperienced (n = 2) readers. Contrast analysis resulted in significantly higher WMSI compared to greyscale analysis (p < 0.003). Of the 83 patients, classified as healthy by greyscale analysis, 55 % were re-classified with motion abnormalities by contrast analysis. No significant difference in EF classification (≥55 %, 45-54 %, 30-44 %, < 30 %) was observed. LV structural abnormalities, such as increased trabeculation (n = 21), apical aneurysm (n = 4), hypertrophy (n = 1) and thrombus (n = 1) were detected during contrast analysis. Intra- and interobserver variability for experienced readers as well as the variability between inexperienced and experienced readers decreased for WMSI and EF after contrast analysis. Contrast-enhanced echocardiography beyond current recommendations for contrast agent usage increased the number of detected wall motion and LV structural abnormalities. Moreover, contrast-enhanced echocardiography increased reproducibility for assessment of WMSI and EF.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Postgraduate 6 20%
Student > Ph. D. Student 3 10%
Student > Master 2 7%
Librarian 1 3%
Other 2 7%
Unknown 10 33%
Readers by discipline Count As %
Medicine and Dentistry 12 40%
Nursing and Health Professions 2 7%
Biochemistry, Genetics and Molecular Biology 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Psychology 1 3%
Other 1 3%
Unknown 12 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2016.
All research outputs
#19,944,091
of 25,374,647 outputs
Outputs from Cardiovascular Ultrasound
#245
of 328 outputs
Outputs of similar age
#278,478
of 400,004 outputs
Outputs of similar age from Cardiovascular Ultrasound
#7
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 328 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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