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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children
|
|---|---|
| Published in |
Behavioral and Brain Functions, January 2016
|
| DOI | 10.1186/s12993-015-0084-6 |
| Pubmed ID | |
| Authors |
Clara I. Gomez-Sanchez, Rosa Riveiro-Alvarez, Victor Soto-Insuga, Maria Rodrigo, Pilar Tirado-Requero, Ignacio Mahillo-Fernandez, Francisco Abad-Santos, Juan J. Carballo, Rafael Dal-Ré, Carmen Ayuso |
| Abstract |
Attention deficit hyperactivity disorder (ADHD) has a strong genetic component. The study is aimed to test the association of 34 polymorphisms with ADHD symptomatology considering the role of clinical subtypes and sex in a Spanish population. A cohort of ADHD 290 patients and 340 controls aged 6-18 years were included in a case-control study, stratified by sex and ADHD subtype. Multivariate logistic regression was used to detect the combined effects of multiple variants. After correcting for multiple testing, we found several significant associations between the polymorphisms and ADHD (p value corrected ≤0.05): (1) SLC6A4 and LPHN3 were associated in the total population; (2) SLC6A2, SLC6A3, SLC6A4 and LPHN3 were associated in the combined subtype; and (3) LPHN3 was associated in the male sample. Multivariable logistic regression was used to estimate the influence of these variables for the total sample, combined and inattentive subtype, female and male sample, revealing that these factors contributed to 8.5, 14.6, 2.6, 16.5 and 8.5 % of the variance respectively. We report evidence of the genetic contribution of common variants to the ADHD phenotype in four genes, with the LPHN3 gene playing a particularly important role. Future studies should investigate the contribution of genetic variants to the risk of ADHD considering their role in specific sex or subtype, as doing so may produce more predictable and robust models. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Greece | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 13% |
| Researcher | 6 | 11% |
| Student > Master | 6 | 11% |
| Other | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Other | 17 | 31% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 22% |
| Agricultural and Biological Sciences | 7 | 13% |
| Psychology | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Neuroscience | 4 | 7% |
| Other | 7 | 13% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2016.
All research outputs
#16,046,765
of 25,371,288 outputs
Outputs from Behavioral and Brain Functions
#228
of 417 outputs
Outputs of similar age
#218,245
of 400,016 outputs
Outputs of similar age from Behavioral and Brain Functions
#6
of 6 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,016 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.