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Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants

Overview of attention for article published in Diagnostic Pathology, January 2016
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Title
Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants
Published in
Diagnostic Pathology, January 2016
DOI 10.1186/s13000-016-0453-y
Pubmed ID
Authors

Pablo Cannata-Ortiz, Carolina Gracia, Youssef Aouad, Antonio Barat, Miguel Angel Martinez-Gonzalez, Gabriela Rossello, Catalina Martin-Cleary, Beatriz Fernández-Fernández, Luis Requena, Alberto Ortiz

Abstract

The systemic consequences of esthetic filler injections are poorly understood. We report a patient with a past history of subcutaneous injection of aesthetic filler material in the lower legs, who presented with post-infectious glomerulonephritis following necrotic leg ulcers at the injection site. Kidney biopsy revealed the presence of translucent, non-birefringent microspherical bodies compatible with polymethylmetacrylate (PMMA) microspheres in some capillary lumens. This had not previously been described. PMMA is a biphasic aesthetical filler composed of polymethylmetacrylate microspheres suspended in a biodegradable bovine collagen carrier. The solid phase (PMMA microspheres) persists in tissues for years. Although PMMA was thought to not disseminate systemically, tissue necrosis may have favored systemic dissemination of the microspheres, although entry in the circulation and microembolization at the time of administration cannot be ruled out. In conclusion, aesthetic filler implants may cause microembolization into small vessels. Recognition of the characteristic morphology may expedite diagnosis and avoid unnecessary further testing.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 16%
Student > Master 2 11%
Other 2 11%
Researcher 2 11%
Lecturer 1 5%
Other 5 26%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 9 47%
Biochemistry, Genetics and Molecular Biology 2 11%
Nursing and Health Professions 1 5%
Immunology and Microbiology 1 5%
Engineering 1 5%
Other 0 0%
Unknown 5 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Diagnostic Pathology
#735
of 1,193 outputs
Outputs of similar age
#278,563
of 400,038 outputs
Outputs of similar age from Diagnostic Pathology
#17
of 27 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 400,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.