Title |
Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants
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Published in |
Diagnostic Pathology, January 2016
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DOI | 10.1186/s13000-016-0453-y |
Pubmed ID | |
Authors |
Pablo Cannata-Ortiz, Carolina Gracia, Youssef Aouad, Antonio Barat, Miguel Angel Martinez-Gonzalez, Gabriela Rossello, Catalina Martin-Cleary, Beatriz Fernández-Fernández, Luis Requena, Alberto Ortiz |
Abstract |
The systemic consequences of esthetic filler injections are poorly understood. We report a patient with a past history of subcutaneous injection of aesthetic filler material in the lower legs, who presented with post-infectious glomerulonephritis following necrotic leg ulcers at the injection site. Kidney biopsy revealed the presence of translucent, non-birefringent microspherical bodies compatible with polymethylmetacrylate (PMMA) microspheres in some capillary lumens. This had not previously been described. PMMA is a biphasic aesthetical filler composed of polymethylmetacrylate microspheres suspended in a biodegradable bovine collagen carrier. The solid phase (PMMA microspheres) persists in tissues for years. Although PMMA was thought to not disseminate systemically, tissue necrosis may have favored systemic dissemination of the microspheres, although entry in the circulation and microembolization at the time of administration cannot be ruled out. In conclusion, aesthetic filler implants may cause microembolization into small vessels. Recognition of the characteristic morphology may expedite diagnosis and avoid unnecessary further testing. |
X Demographics
Geographical breakdown
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 16% |
Student > Master | 2 | 11% |
Other | 2 | 11% |
Researcher | 2 | 11% |
Lecturer | 1 | 5% |
Other | 5 | 26% |
Unknown | 4 | 21% |
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Medicine and Dentistry | 9 | 47% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Nursing and Health Professions | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 26% |